Ruxolitinib (INCB-018424, INCB18424)

Chemical Structure : Ruxolitinib

CAS No.: 941678-49-5

Catalog No.: PC-45872Not For Human Use, Lab Use Only.

Ruxolitinib (INCB-018424) is a potent, selective, orally active JAK1/JAK2 inhibitor with IC50 of 3.3/2.8 nM, respectively.

Packing	Price	Stock
50 mg	$98	In stock
100 mg	$128	In stock
200 mg	$188	In stock
1 g		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Biological Activity

Ruxolitinib (INCB-018424, INCB18424) is a potent, selective, orally active JAK1/JAK2 inhibitor with IC50 of 3.3/2.8 nM, respectively.
Ruxolitinib (INCB-018424) displays modest selectivity against Tyk2 (6-fold) and marked selectivity (>130-fold) against JAK3.
Ruxolitinib (INCB-018424) inhibits IL-6 signaling (IC50=281 nM), and proliferation of JAK2V617F(+) Ba/F3 cells (IC50=127 nM).
Ruxolitinib (INCB-018424) suppresses erythroid progenitor colony formation from JAK2V617F(+) polycythemia vera patients (IC50=67 nM) in primary cultures.
Ruxolitinib (INCB-018424) markedly reduces level of inflammatory cytokines, and preferentially eliminates neoplastic cells in a mouse model of JAK2V617F(+) MPN.

Physicochemical Properties

M.Wt	306.365
Formula	C17H18N6
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	DMSO: ≥ 36 mg/mL; H2O: < 0.1 mg/mL
Chemical Name/SMILES	1H-Pyrazole-1-propanenitrile, β-cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-, (βR)-

References

1. Quintás-Cardama A, et al. Blood. 2010 Apr 15;115(15):3109-17.

2. Fridman JS, et al. J Immunol. 2010 May 1;184(9):5298-307.

3. Verstovsek S, et al. N Engl J Med. 2010 Sep 16;363(12):1117-27.