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Chemical Structure : S-217622
CAS No.: 2647530-73-0
Catalog No.: PC-38178Not For Human Use, Lab Use Only.
S-217622 (Ensitrelvir, S217622) is the first oral, non-covalent, non-peptidic SARS-CoV-2 3C-like protease (3CLpro) inhibitor clinical candidate with biochemical IC50 of 13 nM, antiviral EC50 of 0.37 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $78 | In stock | |
| 25 mg | $128 | In stock | |
| 50 mg | $198 | In stock | |
| 100 mg | $328 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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S-217622 (Ensitrelvir, S217622) is the first oral, non-covalent, non-peptidic SARS-CoV-2 3C-like protease (3CLpro) inhibitor clinical candidate with biochemical IC50 of 13 nM, antiviral EC50 of 0.37 uM.
The antiviral activity of S-217622 against SARS-CoV and SARS-CoV-2 was similar especially at the site where homology of 3CLpro was well conserved.
S-217622 also exhibited potent antiviral ability against the Middle East respiratory syndrome (MERS), human coronavirus OC43 (HCoV-OC43), and human coronavirus 229E (HCoV-229E).
S-217622 exhibited no inhibitory effect against host-cell proteases, such as cathepsin B/D/G/L, caspase-2, chymotrypsin, and thrombin at 100 uM.
S-217622 dose-dependently inhibited intrapulmonary replication of SARS-CoV-2 in mice, and currently under clincial investigation for COVID-19.
| M.Wt | 531.884 | |
| Formula | C22H17ClF3N9O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO (5.3 mg/mL) |
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| Chemical Name/SMILES |
1,3,5-Triazine-2,4(1H,3H)-dione, 6-[(6-chloro-2-methyl-2H-indazol-5-yl)imino]dihydro-3-[(1-methyl-1H-1,2,4-triazol-3-yl)methyl]-1-[(2,4,5-trifluorophenyl)methyl]-, (6E)- |
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1. Yuto Unoh, et al. 2022.
2. Kawaoka Y, et al. Res Sq. 2022 Feb 24:rs.3.rs-1375091.
3. McKimm-Breschkin JL, et al. Antiviral Res. 2022 Jan;197:105227.
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