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Chemical Structure : S-63845
CAS No.: 1799633-27-4
Catalog No.: PC-42244Not For Human Use, Lab Use Only.
S-63845 (S63845) is a highly potent, selective Mcl-1 inhibitor with Kd of 0.19 nM, with no appreciable binding affinity to BCL-2 or BCL-XL (Ki>10 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $258 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | $598 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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S-63845 (S63845) is a highly potent, selective Mcl-1 inhibitor with Kd of 0.19 nM, with no appreciable binding affinity to BCL-2 or BCL-XL (Ki>10 uM).
S-63845 binds to the BH3-binding groove of Mcl-1.
S-63845 potently kills MCL1-dependent cancer cells, including multiple myeloma (IC50<0.1 uM), leukaemia and lymphoma cells, by activating the BAX/BAK-dependent mitochondrial apoptotic pathway.
S-63845 is well tolerated and shopws high effectivity against mouse cancer models.
| M.Wt | 829.2593 | |
| Formula | C39H37ClF4N6O6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO |
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| Chemical Name/SMILES |
Dispiro[cyclohexane-1,2'-[2H]indene-1'(3'H),2''-[2H]imidazol]-4''-amine, 4-methoxy-5''-methyl-6'-[5-(1-propyn-1-yl)-3-pyridinyl]-, (1α,1'R,4β)- |
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1. Kotschy A, et al. Nature. 2016 Oct 27;538(7626):477-482.
2. Merino D, et al. Sci Transl Med. 2017 Aug 2;9(401). pii: eaam7049.
3. Letai A. Cancer Cell. 2016 Dec 12;30(6):834-835.
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