Chemical Structure : S-Y048
CAS No.:
2020058-38-0
S-Y048
((S)-Y048)
Catalog No.: PC-72738Not For Human Use, Lab Use Only.
S-Y048 ((S)-Y048) is a highly potent, selective OXE receptor antagonist, inhibits 5‐oxo‐ETE‐induced calcium mobilization in human neutrophils with pIC50 of 10.8 (20 pM).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
S-Y048 ((S)-Y048) is a highly potent, selective OXE receptor antagonist, inhibits 5‐oxo‐ETE‐induced calcium mobilization in human neutrophils with pIC50 of 10.8 (20 pM).
S‐Y048 (10 nM) completely blocked actin polymerization induced in human eosinophils by 5‐oxo‐ETE.
S‐Y048 had no effect on actin polymerization in eosinophils in response to identical concentrations of PGD2, LTB4, or human eotaxin‐1, S‐Y048 (1 uM) blocked 5‐oxo‐ETE‐induced actin polymerization in neutrophils but had no effect on the response to LTB4.
S-Y048 inhibited allergen-induced eosinophil infiltration into the skin of rhesus monkeys that had been experimentally sensitized to house dust mite and inhibited pulmonary inflammation resulting from challenge with aerosolized allergen.
Physicochemical Properties
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M.Wt
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488.449
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Formula
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C27H31Cl2NO3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Month
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Shipping
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Solubility
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Chemical Name/SMILES
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References
1. Miller LA, et al. Br J Pharmacol. 2020 Jan;177(2):360-371.
2. Ye Q, et al. Br J Pharmacol. 2020 Jan;177(2):388-401.
3. Powell WS, et al. Biochem Pharmacol. 2020 Sep;179:113930.
4. Cossette C, et al. Br J Pharmacol. 2022 Jan;179(2):322-336.
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