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S-Y048

Chemical Structure : S-Y048

CAS No.: 2020058-38-0

S-Y048 ((S)-Y048)

Catalog No.: PC-72738Not For Human Use, Lab Use Only.

S-Y048 ((S)-Y048) is a highly potent, selective OXE receptor antagonist, inhibits 5‐oxo‐ETE‐induced calcium mobilization in human neutrophils with pIC50 of 10.8 (20 pM).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

S-Y048 ((S)-Y048) is a highly potent, selective OXE receptor antagonist, inhibits 5‐oxo‐ETE‐induced calcium mobilization in human neutrophils with pIC50 of 10.8 (20 pM).
S‐Y048 (10 nM) completely blocked actin polymerization induced in human eosinophils by 5‐oxo‐ETE.
S‐Y048 had no effect on actin polymerization in eosinophils in response to identical concentrations of PGD2, LTB4, or human eotaxin‐1, S‐Y048 (1 uM) blocked 5‐oxo‐ETE‐induced actin polymerization in neutrophils but had no effect on the response to LTB4.
S-Y048 inhibited allergen-induced eosinophil infiltration into the skin of rhesus monkeys that had been experimentally sensitized to house dust mite and inhibited pulmonary inflammation resulting from challenge with aerosolized allergen.

Physicochemical Properties

M.Wt 488.449
Formula C27H31Cl2NO3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Month
Shipping
Solubility

Chemical Name/SMILES

References

1. Miller LA, et al. Br J Pharmacol. 2020 Jan;177(2):360-371.

2. Ye Q, et al. Br J Pharmacol. 2020 Jan;177(2):388-401.

3. Powell WS, et al. Biochem Pharmacol. 2020 Sep;179:113930.

4. Cossette C, et al. Br J Pharmacol. 2022 Jan;179(2):322-336.

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