SARS-CoV-2 Mpro inhibitor H102

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Chemical Structure : SARS-CoV-2 Mpro inhibitor H102

Catalog No.: PC-25564Not For Human Use, Lab Use Only.

SARS-CoV-2 Mpro inhibitor H102 is a potent covalent inhibitor of SARS-CoV-2 Mpro with IC50 of 8.8 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SARS-CoV-2 Mpro inhibitor H102 is a potent covalent inhibitor of SARS-CoV-2 Mpro with IC50 of 8.8 nM.
H102 is more potent than another reported aldehyde Mpro inhibitor GC376 (IC50 of 24.5 nM) and Nirmatrelvir (PF-07321332, IC50 of 22.2 nM).
H102 effectively decreases viral replication by 3.55 log10 at 10 µM and 1.34 log10 at 2.5 µM, respectively, in VeroE6 cells by viral load reduction assay.
H102 inhibits viral replication with an EC50 of 168.9 nM in VeroE6 cells without cytotoxicity at >50 uM.

Physicochemical Properties

M.Wt	498.62
Formula	C24H42N4O7
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(6S,9S,12S)-6-(tert-butyl)-9-isobutyl-2,2-dimethyl-4,7,10-trioxo-12-(((S)-2-oxopyrrolidin-3-yl)methyl)-3-oxa-5,8,11-triazatridecan-13-oic acid

References

1. Wang J, et al. J Virol. 2025 Sep 15:e0065825.

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