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Chemical Structure : SCH-00013
CAS No.: 217963-18-3
Catalog No.: PC-42235Not For Human Use, Lab Use Only.
A novel cardiotonic agent that acts as a calcium sensitizer with no chronotropic activity in mammalian cardiac muscle, elicits positive inotropic effect in dog and rabbit ventricular muscles (EC50=9.2 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $360 | In stock | |
| 10 mg | $520 | In stock | |
| 25 mg | $1040 | In stock |
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A novel cardiotonic agent that acts as a calcium sensitizer with no chronotropic activity in mammalian cardiac muscle, elicits positive inotropic effect in dog and rabbit ventricular muscles (EC50=9.2 uM); also weakly inhibits PDE3 with IC50 of 64.9 uM; improved left ventricular dysfunction and survival prognosis of dilated cardiomyopathy in a mouse model; orally bioavailable.
Heart Failure
Preclinical
| M.Wt | 324.377 | |
| Formula | C18H20N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO |
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| Chemical Name/SMILES |
Benzonitrile, 4-[2-[3,6-dihydro-4-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)-1(2H)-pyridinyl]-1-hydroxyethyl]- |
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1. Sugawara H, et al. J Pharmacol Exp Ther. 1998 Oct;287(1):214-22.
2. Hino M, et al. Arzneimittelforschung. 1999 May;49(5):398-406.
3. Yoshimura A, et al. Arzneimittelforschung. 1999 May;49(5):407-11.
4. Arimura T, et al. J Am Coll Cardiol. 2010 Apr 6;55(14):1503-5.
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