Ecopipam (SCH 39166) is a potent, selective D1 dopamine receptor antagonist with Ki of 3.6 nM, >300-fold selectivity over D2 and 5-HT2 receptors.
Ecopipam (SCH 39166) blocks dopamine-stimulated adenylate cyclase with Ki of 9.1 nM, inhibits both rat and squirrel monkey conditioned avoidance responding.
Ecopipam (SCH 39166) antagonizes apomorphine-induced stereotypy in rats, demonstrates potential antipsychotic activity in vivo.
