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Chemical Structure : SCH39166
Catalog No.: PC-60812Not For Human Use, Lab Use Only.
A potent, selective D1 dopamine receptor antagonist with Ki of 3.6 nM, >300-fold selectivity over D2 and 5-HT2 receptors.
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A potent, selective D1 dopamine receptor antagonist with Ki of 3.6 nM, >300-fold selectivity over D2 and 5-HT2 receptors; blocks dopamine-stimulated adenylate cyclase with Ki of 9.1 nM, inhibits both rat and squirrel monkey conditioned avoidance responding; antagonizes apomorphine-induced stereotypy in rats, demonstrates potential antipsychotic activity in vivo.
| M.Wt | 394.73 | |
| Formula | C19H20ClNO.HBr | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Chipkin RE, et al. J Pharmacol Exp Ther. 1988 Dec;247(3):1093-102.
2. Lidow MS, et al. Brain Res. 1990 Dec 24;537(1-2):349-54.
3. Wu WL, et al. J Med Chem. 2005 Feb 10;48(3):680-93.
4. Criswell HE, et al. Neuropsychopharmacology. 1992 Sep;7(2):95-103.
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