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SCH 58261

Chemical Structure : SCH 58261

CAS No.: 160098-96-4

SCH 58261 (SCH-58261;SCH58261)

Catalog No.: PC-45642Not For Human Use, Lab Use Only.

SCH 58261 is a potent and selective, competitive A2A adenosine receptor antagonist with Ki of 2.3 nM and 2.0 nM in rat and bovine brain, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

SCH 58261 is a potent and selective, competitive A2A adenosine receptor antagonist with Ki of 2.3 nM and 2.0 nM in rat and bovine brain, respectively.
SCH 58261 displays 323-, 53- and 100-fold selectivity over A1, A2B and A3 receptors, respectively.
SCH 58261 reverses reperfusion injury (IR) increased hippocampal Glu, GABA, glycine and aspartate, MPO, TNF-α, nitric oxide, and PGE in Male Wistar rats.

Physicochemical Properties

M.Wt 345.358
Formula C18H15N7O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 34 mg/mL

Chemical Name/SMILES

7H-Pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine, 2-(2-furanyl)-7-(2-phenylethyl)-

References

1. Zocchi C, et al. J Pharmacol Exp Ther. 1996 Feb;276(2):398-404.

2. Beavis PA, et al. Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):14711-6.

3. Mohamed RA, et al. Neurochem Res. 2012 Mar;37(3):538-47.

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