SCoV2 Plpro-IN-19

Chemical Structure : SCoV2 Plpro-IN-19

Catalog No.: PC-72490Not For Human Use, Lab Use Only.

SCoV2 Plpro-IN-19 is a potent and selective inhibitor targeting the papain-like protease of SARS-CoV-2 (SCoV2 PLpro) with IC50 of 0.44 uM, binding Kd of 2.6 uM.

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Biological Activity

SCoV2 Plpro-IN-19 is a potent and selective inhibitor targeting the papain-like protease of SARS-CoV-2 (SCoV2 PLpro) with IC50 of 0.44 uM, binding Kd of 2.6 uM.
SCoV2 Plpro-IN-19 displays no inhibitory effect at 10 uM against 10 DUBs or DUB-like proteases, including USP14 and OTUB1.
SCoV2 Plpro-IN-19 significantly inhibited SCoV2 PLpro in 293T cells at 10 uM.
SCoV2 Plpro-IN-19 efficiently suppressed viral replication of with a submicromolar IC50 0.18 uM without cytotoxicity (CC50>50 uM).

Physicochemical Properties

M.Wt	531.676
Formula	C31H38FN5O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Month
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Solubility
Chemical Name/SMILES

References

1. Hengyue Shan, et al. Cell Chem Biol. 2021 Jun 17;28(6):855-865.e9.

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SCoV2 Plpro-IN-19

Biological Activity

Physicochemical Properties

References

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