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Chemical Structure : SEL24-B489
Catalog No.: PC-63507Not For Human Use, Lab Use Only.
SEL24-B489 (SEL24, MEN1703) is a potent, dual PIM and FLT3-ITD inhibitor with Kd of 2/2/3 nM for PIM1/2/3, Kd of 160/16 nM for FLT3-WT/FLT3-ITD, respectively.
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SEL24-B489 (SEL24, MEN1703) is a potent, dual PIM and FLT3-ITD inhibitor with Kd of 2/2/3 nM for PIM1/2/3, Kd of 160/16 nM for FLT3-WT/FLT3-ITD, respectively.
SEL24-B489 exhibits significantly broader on-target activity in AML cell lines (MV-4-11 GI50=20 nM) and primary AML blasts than selective FLT3-ITD or PIM inhibitors.
SEL24-B489 decreases viability of AML cells with FLT3-TKD mutations associated with resistance to selective FLT3-ITD inhibitors.
SEL24-B489 inhibits the growth of a broad panel of AML cell lines in xenograft models.
| M.Wt | 446.143 | |
| Formula | C15H18Br2N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Czardybon W, et al. Oncotarget. 2018 Mar 30;9(24):16917-16931.
2. Białopiotrowicz E, et al. J Cell Mol Med. 2018 Apr 17. doi: 10.1111/jcmm.13632.
3. Szydłowski M, et al. Blood. 2017 Sep 21;130(12):1418-1429.
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