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Chemical Structure : SH5-07
CAS No.: 1456632-41-9
Catalog No.: PC-42175Not For Human Use, Lab Use Only.
SH5-07 (SH-5-07, SH 5-07) is a potent, selective small-molecule STAT3 inhibitor with IC50 of 3.9 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $358 | In stock | |
| 50 mg | $548 | In stock | |
| 100 mg | Get quote |
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SH5-07 (SH-5-07, SH 5-07) is a potent, selective small-molecule STAT3 inhibitor with IC50 of 3.9 uM.
SH5-07 preferentially inhibits Stat3:Stat3 DNA-binding activity, shows no inhibition of Stat1:Stat1 or Stat5:Stat5 activity.
SH5-07 exerts pY705 Stat3 inhibition in human glioma, breast, and prostate cancer cells, blocks STAT3-dependent gene transcription along with Bcl-2, Bcl-xL, Mcl-1, cyclin D1, c-Myc, and survivin expression.
SH5-07 decreases the proliferation and viability of glioma, breast, and prostate cancer cells and v-Src-transformed murine fibroblasts harboring constitutively active STAT3.
SH5-07 effectively inhibits tumor growth in mouse xenograft models of glioma and breast cancer.
| M.Wt | 625.6068 | |
| Formula | C29H28F5N3O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 10 mM |
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| Chemical Name/SMILES |
Benzamide, 4-[[(4-cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]-N-hydroxy- |
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1. Yue P, et al. Cancer Res. 2016 Feb 1;76(3):652-63.
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