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Chemical Structure : SKI-2852
Catalog No.: PC-61137Not For Human Use, Lab Use Only.
SKI-2852 is a highly potent, selective, and orally bioavailable 11β-HSD1 inhibitor with IC50 of 2.9 and 1.6 nM for hHSD1 and mHSD1, respectively.
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SKI-2852 is a highly potent, selective, and orally bioavailable 11β-HSD1 inhibitor with IC50 of 2.9 and 1.6 nM for hHSD1 and mHSD1, respectively.
SKI-2852 demonstrates no CYP and PXR liabilities, excellent PK profiles across species, and highly potent and sustainable PD activity.
SKI-2852 significantly reduces blood glucose and HbA1c levels and improves the lipid profiles in ob/ob mice, synergistically enhances the HbA1c-lowering effect of metformin in vivo.
| M.Wt | 543.658 | |
| Formula | C27H34FN5O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ryu JH, et al. J Med Chem. 2016 Nov 23;59(22):10176-10189.
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