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Chemical Structure : SMER-28
CAS No.: 307538-42-7
Catalog No.: PC-42080Not For Human Use, Lab Use Only.
SMER28 is a small-molecule enhancer/inducer of Autophagy, SMER28 is a small molecule activator of VCP/p97.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $188 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | $458 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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SMER28 is a small-molecule enhancer/inducer of Autophagy, SMER28 is a small molecule activator of VCP/p97.
SMER28 decreases the levels of Aβ peptide (EC50=10 uM) and APP-CTF (EC50 of 20 uM) in a γ-secretase-independent manner in primary neuronal cultures, Atg5, Beclin1 and Ulk1 are shown to be involved in the degradation of Aβ and APP-CTF.
SMER28 enhances erythropoiesis in a range of in vitro and in vivo models of DBA, and protects against neurodegeneration in Drosophila model of Huntington’s disease.
| M.Wt | 264.1212 | |
| Formula | C11H10BrN3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 32 mg/mL |
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| Chemical Name/SMILES |
4-Quinazolinamine, 6-bromo-N-2-propen-1-yl- |
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1. Doulatov S, et al. Sci Transl Med. 2017 Feb 8;9(376). pii: eaah5645.
2. Rosenthal AK, et al. J Biol Chem. 2015 May 22;290(21):13028-38.
3. Sarkar S, et al. Nat Chem Biol. 2007 Jun;3(6):331-8.
4. Tian Y et al. FASEB J. 2011 Jun;25(6):1934-42.
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