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Chemical Structure : SNX-2112
CAS No.: 908112-43-6
Catalog No.: PC-62491Not For Human Use, Lab Use Only.
SNX-2112 (PF-04928473) is a potent, selective Hsp90 inhibitor with binding IC50 of 30 nM for both HSP90α and HSP90β.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $148 | In stock | |
| 10 mg | $238 | In stock | |
| 25 mg | $388 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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SNX-2112 (PF-04928473) is a potent, selective Hsp90 inhibitor with binding IC50 of 30 nM for both HSP90α and HSP90β.
SNX-2112 shows weak affinity for Hsp90 family members Grp94 and Trap-1 (IC50=0.8-4.2 uM).
SNX-2112 has properties and potency, including degradation of HER2, mutant EGFR, and other client proteins, inhibition of ERK and Akt activation, and induction of a Rb-dependent G1 arrest with subsequent apoptosis.
SNX-2112 is the orally bioavailbe prodrug SNX-5422, inhibits MM cell growth and prolongs survival in a xenograft murine model.
| M.Wt | 464.489 | |
| Formula | C23H27F3N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-(6,6-Dimethyl-4-oxo-3-trifluoromethyl-4,5,6,7-tetrahydro-indazol-1-yl)-2-(trans-4-hydroxy-cyclohexylamino)-benzamide |
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1. Okawa Y, et al. Blood. 2009 Jan 22;113(4):846-55.
2. Chandarlapaty S, et al. Clin Cancer Res. 2008 Jan 1;14(1):240-8.
3. Bachleitner-Hofmann T, et al. Clin Cancer Res. 2011 Jan 1;17(1):122-33.
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