Catalog No.: PC-43122Not For Human Use, Lab Use Only.
SP2509 is a potent, selective histone demethylase LSD1 (KDM1A) inhibitor with IC50 of 13 nM, shows no activity against MAOA, MAOB, LDH and glucose oxidase.
SP2509 is a potent, selective histone demethylase LSD1 (KDM1A) inhibitor with IC50 of 13 nM, shows no activity against MAOA, MAOB, LDH and glucose oxidase.
SP2509 inhibits the colony growth of OCI-AML3 significantly more than of the other AML cell-types, induces more apoptosis of AML cells expressing mutant NPM1 than mixed-lineage leukemia fusion oncoproteins.
SP2509 significantly improves the survival of immune-depleted mice model of AML.
SP2509 is synergistically lethal against cultured and primary AML blasts combined with panobinostat.
