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Chemical Structure : SRI‐42127
Catalog No.: PC-47001Not For Human Use, Lab Use Only.
SRI-42127 is a small molecule, BBB-permeable inhibitor of the RNA regulator HuR, inhibits HuR dimerization with IC50 of 1.2 uM in cell-based assays, prevents HuR oligomerization.
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SRI-42127 is a small molecule, BBB-permeable inhibitor of the RNA regulator HuR, inhibits HuR dimerization with IC50 of 1.2 uM in cell-based assays, prevents HuR oligomerization.
SRI-42127 suppressed glioma progression in U251, LN229, and the PDGx XD456 glioma cell lines with IC50 of 2.8-4.0 uM.
SRI-42127 induced apoptosis and reduce tumorigenicity in established and PDGx glioma cell lines.
SRI-42127 (15 mg/kg) exhibited encouraging glioma-inhibitory potential in vivo.
SRI-42127 potently attenuated glial activation in model of lipopolysaccharide-induced neuroinflammation.
| M.Wt | 347.422 | |
| Formula | C20H21N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Filippova N, et al. Cancer Res. 2021 Apr 15;81(8):2220-2233.
2. Chellappan R, et al. Glia. 2022 Jan;70(1):155-172.
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