Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : ST-2825
CAS No.: 894787-30-5
Catalog No.: PC-45910Not For Human Use, Lab Use Only.
ST-2825 (ST2825) is a synthetic peptido-mimetic compound that inhibits MyD88 dimerization in a TIR-dependent manner.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $598 | In stock | |
| 5 mg | $898 | In stock | |
| 10 mg | Get quote | ||
| 25 mg | Get quote | ||
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
ST-2825 (ST2825) is a synthetic peptido-mimetic compound that inhibits MyD88 dimerization in a TIR-dependent manner.
ST-2825 interferes with recruitment of IRAK1 and IRAK4 by MyD88, causing inhibition of IL-1beta-mediated activation of NF-kappaB transcriptional activity.
ST-2825 inhibits IL-1beta-induced production of IL-6 in treated mice, suppresses B cell proliferation and differentiation into plasma cells in response to CpG-induced activation of TLR9.
ST-2825 is orally active.
| M.Wt | 591.506 | |
| Formula | C27H28Cl2N4O5S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
Spiro[pyrrolidine-2,7'(6'H)-[2H]pyrrolo[2,1-b][1,3]thiazine]-4'-carboxamide, 1-[2-[4-[[2-(2,4-dichlorophenoxy)acetyl]amino]phenyl]acetyl]tetrahydro-6'-oxo-, (2R,4'R,8'aR)- |
|
1. Loiarro M, et al. J Leukoc Biol. 2007 Oct;82(4):801-10.
2. Van Tassell BW, et al. Pharmacol. 2011 Feb;57(2):272.
3. Capolunghi F, et al. Rheumatology (Oxford). 2010 Dec;49(12):2281-9.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
