Chemical Structure : SYL1073
CAS No.:
2964520-80-5
SYL1073
(SYL 1073, SYL-1073)
Catalog No.: PC-21597Not For Human Use, Lab Use Only.
SYL1073 is a potent, selective and covalent Threonine tyrosine kinase (TTK) inhibitor with IC50 of of 16 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SYL1073 is a potent, selective and covalent Threonine tyrosine kinase (TTK) inhibitor with IC50 of of 16 nM.
SYL1073 covalently engages with TTK at the C604 residue.
SYL1073 exhibits potent anti-proliferative activity in both MDA-MB-231 (IC50 = 0.13 μM) and HCT-116 (IC50 = 0.15 μM) cell lines.
SYL1073 exhibits excellent kinase selectivity in a panel of kinases, does not inhibit five other human kinases (CHAK1, FGFR4, MAPKAPK2, MAPKAPK3 and p70S6Kβ) that feature a cysteine residue at the equivalent position as C604 in TTK kinase.
SYL1073 effectively suppresses colony formation and induce cell cycle dysregulation and apoptosis in human breast cancer cells.
Physicochemical Properties
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M.Wt
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471.57
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Formula
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C25H29N9O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(5-(4-methyl-4H-1,2,4-triazol-3-yl)-2-((6-methyl-8-(neopentylamino)pyrido[3,4-d]pyrimidin-2-yl)amino)phenyl)acrylamide
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References
1. Yaoliang Sun, et al. Bioorg Chem. 2023 Dec 25:143:107053.
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