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Skp2-IN-C1

Chemical Structure : Skp2-IN-C1

CAS No.: 432001-69-9

Skp2-IN-C1 (CKS1i)

Catalog No.: PC-62453Not For Human Use, Lab Use Only.

Skp2-IN-C1 is a specific small molecule inhibitor of Skp2-mediated p27 degradation, induces p27 accumulation in a Skp2-dependent manner and promoted cell-type-specific blocks in the G1 or G2/M phases.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Skp2-IN-C1 is a specific small molecule inhibitor of Skp2-mediated p27 degradation, induces p27 accumulation in a Skp2-dependent manner and promoted cell-type-specific blocks in the G1 or G2/M phases.

Physicochemical Properties

M.Wt 465.336
Formula C18H13BrN2O4S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(Z)-2-(4-bromo-2-((4-oxo-3-(pyridin-3-ylmethyl)-2-thioxothiazolidin-5-ylidene)methyl)phenoxy)acetic acid

References

1. Wu L, et al. Chem Biol. 2012 Dec 21;19(12):1515-24.

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