Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Smo inhibitor SAG
CAS No.: 912545-86-9
Catalog No.: PC-43256Not For Human Use, Lab Use Only.
SAG is a small molecule Hedgehog (Hh) pathway agonist with EC50 of 3 nM, specifically binds to the Smoothened (Smo) heptahelical bundle (Kd=59 nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $248 | In stock | |
| 25 mg | $398 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
SAG is a small molecule Hedgehog (Hh) pathway agonist with EC50 of 3 nM, specifically binds to the Smoothened (Smo) heptahelical bundle (Kd=59 nM).
SAG effectively activates Shh target gene transcription through the Smoothened (Smo) protein, acts downstream of Ptch1 in the Hh pathway and counteracts cyclopamine inhibition of Smo.
SAG increases Cldn5 expression, decreases endoneurial capillary permeability, and restores thermal algesia to diabetic mice.
SAG inhibits melanin synthesis in melanocytes and pigmentation in a human skin model.
| M.Wt | 490.0594 | |
| Formula | C28H28ClN3OS | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
DMSO: ≥ 38 mg/mL |
|
| Chemical Name/SMILES |
Benzo[b]thiophene-2-carboxamide, 3-chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]- |
|
1. Chen JK, et al. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14071-6.
2. Choi H, et al. PLoS One. 2016 Dec 12;11(12):e0168025.
3. Stanton BZ, et al. Nat Chem Biol. 2009 Mar;5(3):154-6.
4. Chapouly C, et al. Cardiovasc Res. 2016 Feb 1;109(2):217-27.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
