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Chemical Structure : T. cruzi bc1 inhibitor compound 4
Catalog No.: PC-21591Not For Human Use, Lab Use Only.
T. cruzi bc1 inhibitor compound 4 is a highly selective and efficacious T. cruzi cytochrome b inhibitor with IC50 of 6 nM, exhibits potent activity against intracellular amastigotes with EC50 of 0.08 uM.
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T. cruzi bc1 inhibitor compound 4 is a highly selective and efficacious T. cruzi cytochrome b inhibitor with IC50 of 6 nM, exhibits potent activity against intracellular amastigotes with EC50 of 0.08 uM.
T. cruzi bc1 inhibitor compound 4 displays no apparent cytotoxicity against either Vero host cells or uninfected HepG2 cells (pEC50 < 4.5).
T. cruzi bc1 inhibitor compound 4 does not inhibit human complex III, does not reduces the calcium loading capacity (CLC) of isolated rat liver mitochondria at 200 uM.
T. cruzi bc1 inhibitor compound 4 (50, 30, or 10 mg/kg bid) exhibits full efficacy against experimental chronic Chagas disease when dosed orally for 5 days in combination with benznidazole (BNZ).
T. cruzi bc1 inhibitor 4 inhibits the Qi active site of T. cruzi cytochrome b, part of the cytochrome bc1 complex of the electron transport chain.
| M.Wt | 298.35 | |
| Formula | C16H18N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Silvia González, et al. Sci Transl Med. 2023 Dec 13;15(726):eadg8105.
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