Chemical Structure : T6167923
Catalog No.: PC-35814Not For Human Use, Lab Use Only.
T6167923 (T-6167923) is a small molecule inhibitor of MyD88-dependent signaling pathways, disrupts MyD88 homodimeric formation.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
T6167923 (T-6167923) is a small molecule inhibitor of MyD88-dependent signaling pathways, disrupts MyD88 homodimeric formation; inhibits SEB-induced inhibition of cytokine production in PBMCs with IC50 of 2-10 uM, also inhibits SEA-induced pro-inflammatory cytokine production, shows no toxicity in primary cells up to 100 uM; specifically inhibits TIR domain-mediated dimerization of full-length MyD88 as well as the recombinant TIR domain protein; dose-dependent in vivo therapeutic efficacy against SEB intoxication.
M.Wt | 458.389 | |
Formula | C17H20BrN3O3S2 | |
Appearance | Solid | |
Storage |
|
|
Solubility |
10 mM in DMSO |
1. Olson MA, et al. Sci Rep. 2015 Sep 18;5:14246.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright