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Chemical Structure : TASP0433864
Catalog No.: PC-60822Not For Human Use, Lab Use Only.
TASP0433864 is a potent, selective mGluR2 positive allosteric modulator with EC50 of 199 and 206 nM for human and rat mGlu2, respectively, without exerting agonist activity.
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TASP0433864 is a potent, selective mGluR2 positive allosteric modulator with EC50 of 199 and 206 nM for human and rat mGlu2, respectively, without exerting agonist activity.
TASP0433864 has negligible activities for other mGlu receptors, including mGlu3 receptor.
TASP0433864 potentiates the mGlu2 receptor-mediated presynaptic inhibition of glutamate release, inhibits both MK-801- and ketamine-increased cortical γ band oscillation in the rat cortical electroencephalogram.
TASP0433864 significantly inhibits both ketamine- and methamphetamine-increased locomotor activities in mice.
| M.Wt | 329.4 | |
| Formula | C18H23N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hiyoshi T, et al. J Pharmacol Exp Ther. 2014 Dec;351(3):642-53.
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