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Chemical Structure : TCH-165
CAS No.: 1446350-60-2
Catalog No.: PC-35491Not For Human Use, Lab Use Only.
TCH-165 is a specific small molecule modulator of proteasome assembly, regulates the dynamic equilibrium between the 20S and 26S proteasome complexes, favoring 20S-mediated protein degradation.
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|---|---|---|---|
| 5 mg | $258 | In stock | |
| 10 mg | $428 | In stock | |
| 25 mg | $728 | In stock | |
| 100 mg | Get quote |
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TCH-165 is a specific small molecule modulator of proteasome assembly, regulates the dynamic equilibrium between the 20S and 26S proteasome complexes, favoring 20S-mediated protein degradation.
TCH-165 enhances the degradation of both α-syn and tau, does not induce the degradation of GAPDH, enhances the degradation of intrinsically disordered proteins in cell culture.
TCH-165 display a decrease in assembled 26S and an increase in 20S proteasome in treated cells.
| M.Wt | 595.743 | |
| Formula | C39H37N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
ethyl (4R,5R)-1-benzyl-5-(4-(benzylamino)phenyl)-2-(4-methoxyphenyl)-4-phenyl-4,5-dihydro-1H-imidazole-4-carboxylate |
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1. Njomen E, et al. Biochemistry. 2018 Jul 17;57(28):4214-4224.
2. Azevedo LM, et al. J Med Chem. 2013 Jul 25;56(14):5974-8.
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