Chemical Structure : TKB272
CAS No.:
2892688-18-3
TKB272
(TBK-272)
Catalog No.: PC-23891Not For Human Use, Lab Use Only.
TKB272 is a potent, selective inhibitor of SARS-CoV-2 main protease (Mpro) with IC50 of 0.7 nM, effectively blocks the infectivity and replication of SARS-CoV-2 strains (SARS-CoV-2 WK-521, EC50=7.0 nM, VeroE6 cell).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
TKB272 is a potent, selective inhibitor of SARS-CoV-2 main protease (Mpro) with IC50 of 0.7 nM, effectively blocks the infectivity and replication of SARS-CoV-2 strains (SARS-CoV-2 WK-521, EC50=7.0 nM, VeroE6 cell).
TKB272 inhibits Omicron variants such as SARS-CoV-2XBB1.5 and SARS-CoV-2EG.5.1.
TKB272 blockes SARS-CoV-2XBB1.5 replication without ritonavir in B6.Cg-Tg(K18-hACE2)2-Prlmn/J-transgenic mice. TKB272 shows no apparent genotoxicity as tested in the micro-Ames test.
Physicochemical Properties
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M.Wt
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653.69
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Formula
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C30H35F4N5O5S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(1R,2S,5S)-3-((S)-3,3-dimethyl-2-(2,2,2-trifluoroacetamido)butanoyl)-N-((S)-1-(5-fluorobenzo[d]thiazol-2-yl)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide
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References
1. Higashi-Kuwata N, et al. PNAS Nexus. 2025 Jan 7;4(1):pgae578.
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