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Chemical Structure : TMP-195
CAS No.: 1314891-22-9
Catalog No.: PC-60293Not For Human Use, Lab Use Only.
TMP-195 is a first-in-class, potent, selective class IIa HDACs (HDAC4, HDAC5, HDAC7 and HDAC9) inhibtior with IC50 of 60, 59, 26, and 15 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $278 | In stock | |
| 100 mg | $598 | In stock | |
| 250 mg | Get quote | ||
| 1 g | Get quote |
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TMP-195 is a first-in-class, potent, selective class IIa HDACs (HDAC4, HDAC5, HDAC7 and HDAC9) inhibtior with IC50 of 60, 59, 26, and 15 nM, respectively.
TMP-195 shows no significant inhibition for others HDACs.
TMP-195 alters the tumour microenvironment and reduces tumour burden and pulmonary metastases by modulating macrophage phenotypes in mice.
TMP-195 induces the recruitment and differentiation of highly phagocytic and stimulatory macrophages within tumours.
| M.Wt | 456.42 | |
| Formula | C23H19F3N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(2-methyl-2-(2-phenyloxazol-4-yl)propyl)-3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide |
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1. Lobera M, et al. Nat Chem Biol. 2013 May;9(5):319-25.
2. Guerriero JL, et al. Nature. 2017 Mar 16;543(7645):428-432.
3. Cassetta L, et al. Cell Res. 2017 Aug;27(8):963-964.
4. Groselj B, et al. Mol Cancer Ther. 2017 Aug 24. pii: molcanther.0011.2017.
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