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Chemical Structure : TMP-269
CAS No.: 1314890-29-3
Catalog No.: PC-45462Not For Human Use, Lab Use Only.
TMP-269 (TMP269) is a potent and selective class IIa HDAC inhibitor with IC50s of 126/80/36/19 nM for HDAC4/5/7/9.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $198 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $458 | In stock | |
| 100 mg | Get quote | ||
| 200 mg | Get quote | ||
| 1 g | Get quote |
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TMP-269 (TMP269) is a potent and selective class IIa HDAC inhibitor with IC50s of 126/80/36/19 nM for HDAC4/5/7/9.
TMP-269 is less potent or no inhibition for others HDAC isoforms (>2 uM).
TMP-269 prevents cell cycle progression, DNA synthesis, and proliferation induced in response to G protein-coupled receptor/PKD1 activation in IEC-18 cells.
| M.Wt | 514.5195 | |
| Formula | C25H21F3N4O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 41 mg/mL |
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| Chemical Name/SMILES |
Benzamide, N-[[tetrahydro-4-(4-phenyl-2-thiazolyl)-2H-pyran-4-yl]methyl]-3-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]- |
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1. Lobera M, et al. Nat Chem Biol. 2013 May;9(5):319-25.
2. Sinnett-Smith J, et al. Am J Physiol Cell Physiol. 2014 May 15;306(10):C961-71.
3. Kikuchi S, et al. Leukemia. 2015 Sep;29(9):1918-27.
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