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TMP-269

Chemical Structure : TMP-269

CAS No.: 1314890-29-3

TMP-269 (TMP 269, TMP269)

Catalog No.: PC-45462Not For Human Use, Lab Use Only.

TMP-269 (TMP269) is a potent and selective class IIa HDAC inhibitor with IC50s of 126/80/36/19 nM for HDAC4/5/7/9.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

TMP-269 (TMP269) is a potent and selective class IIa HDAC inhibitor with IC50s of 126/80/36/19 nM for HDAC4/5/7/9.
TMP-269 is less potent or no inhibition for others HDAC isoforms (>2 uM).
TMP-269 prevents cell cycle progression, DNA synthesis, and proliferation induced in response to G protein-coupled receptor/PKD1 activation in IEC-18 cells.

Physicochemical Properties

M.Wt 514.5195
Formula C25H21F3N4O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 41 mg/mL

Chemical Name/SMILES

Benzamide, N-[[tetrahydro-4-(4-phenyl-2-thiazolyl)-2H-pyran-4-yl]methyl]-3-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]-

References

1. Lobera M, et al. Nat Chem Biol. 2013 May;9(5):319-25.

2. Sinnett-Smith J, et al. Am J Physiol Cell Physiol. 2014 May 15;306(10):C961-71.

3. Kikuchi S, et al. Leukemia. 2015 Sep;29(9):1918-27.

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