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Chemical Structure : Tofacitinib
CAS No.: 477600-75-2
Catalog No.: PC-45816Not For Human Use, Lab Use Only.
Tofacitinib (CP-690550) is a potent, specific, orally active inhibitor of JAK3 with IC50 of 1 nM in cell-free assays.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg (Free Sample) | $28 | In stock | |
| 50 mg | $148 | In stock | |
| 100 mg | $228 | In stock | |
| 250 mg | $358 | In stock | |
| 1 g | Get quote |
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Tofacitinib (CP-690550) is a potent, specific, orally active inhibitor of JAK3 with IC50 of 1 nM in cell-free assays.
Tofacitinib (CP-690550) displays 20- to 100-fold less potency for JAK2 and JAK1 (IC50=20 nM and 112 nM, respectively), and shows no potent activity against 30 other kinases at >3 uM (CaMK1, ROCK2, Lck, MST2, etc.).
Tofacitinib (CP-690550) effectively inhibits a murine mixed lymphocyte reaction (MLR) with IC50 of 91 nM.
Tofacitinib (CP-690550) significantly prolonges survival in a murine model of heart transplantation and in cynomolgus monkeys receiving kidney transplants.
| M.Wt | 312.37 | |
| Formula | C16H20N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 100 mM (31.2 mg/mL); H2O: <1 mM (<0.3 mg/mL) |
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| Chemical Name/SMILES |
1-Piperidinepropanenitrile, 4-methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-.beta.-oxo-, (3R,4R)- |
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1. Changelian PS, et al. Science. 2003 Oct 31;302(5646):875-8.
2. Jiang JK, et al. J Med Chem. 2008 Dec 25;51(24):8012-8.
3. Kudlacz E, et al. Am J Transplant. 2004 Jan;4(1):51-7.
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