Chemical Structure : TopBP1 inhibitor 5D4
CAS No.:
1212595-23-7
TopBP1 inhibitor 5D4
Catalog No.: PC-21291Not For Human Use, Lab Use Only.
TopBP1 inhibitor 5D4 is a small-molecule inhibitor of TopBP1 (topoisomerase IIβ-binding protein 1), specifically targets the BRCT7/8 domains of TopBP1, blocks MYC activity by freeing MIZ1, a MYC inhibitor, from TopBP1.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
TopBP1 inhibitor 5D4 is a small-molecule inhibitor of TopBP1 (topoisomerase IIβ-binding protein 1), specifically targets the BRCT7/8 domains of TopBP1, blocks MYC activity by freeing MIZ1, a MYC inhibitor, from TopBP1.
TopBP1 inhibitor 5D4 also inhibits Rad51 foci formation and synergize with inhibitors of PARP1/2 or PARP14.
TopBP1 (topoisomerase IIβ-binding protein 1) functions at the convergent point of Rb, PI3K/Akt, and p53 pathways, making it a promising cancer therapeutic target.
Physicochemical Properties
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M.Wt
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466.63
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Formula
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C30H34N4O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(4-methoxybenzyl)-1-(5-(1-methyl-3-(naphthalen-2-yl)-1H-pyrazol-5-yl)quinuclidin-2-yl)methanamine
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References
1. Fang-Tsyr Lin, et al. Proc Natl Acad Sci U S A. 2023 Oct 31;120(44):e2307793120.
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