Catalog No.: PC-43314Not For Human Use, Lab Use Only.
Torin1 is a highly potent, selective inhibitor of mTORC1 and mTORC2 with IC50 of 2 and 10 nM in cell-free assays, exhibits 1,000-fold selectivity PI3K (EC50=1,800 nM).
Torin1 is a highly potent, selective inhibitor of mTORC1 and mTORC2 with IC50 of 2 and 10 nM in cell-free assays, exhibits 1,000-fold selectivity PI3K (EC50=1,800 nM).
Torin1 exhibits 100-fold binding selectivity relative to 450 other protein kinases.
Torin1 causes cell cycle arrest through a rapamycin-resistant mechanism that is also independent of mTORC2, disrupts mTORC1-dependent phenotypes more completely than rapamycin.
Torin1 prevents the anti-inflammatory potency of GC both in human monocytes and myeloid dendritic cells.
