UBCS373 | Sirtuin 4 inhibitor | Probechem Biochemicals

Chemical Structure : UBCS373

UBCS373 (Sirt4 inhibitor 69)

Catalog No.: PC-21715Not For Human Use, Lab Use Only.

UBCS373 (Sirt4 inhibitor 69) is a highly isoform selective inhibitor of mitochondrial deacylase Sirtuin 4 (Sirt4) with IC50 of 16 uM.

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Biological Activity

UBCS373 (Sirt4 inhibitor 69) is a highly isoform selective inhibitor of mitochondrial deacylase Sirtuin 4 (Sirt4) with IC50 of 16 uM.
UBCS373 displays high selectivity against Sirt1, −2, −3, −5, and −6.
UBCS373 inhibits Sirt4 through binding to active site regions overlapping with the acyl-peptide binding regions but not with the NAD+ site.
UBCS373 dose-dependently increases GDH activity in both whole cells and mitochondrial extract of C2C12 mouse myoblast cells.
UBCS373 is active in cells and can serve as a chemical tool for physiological studies on Sirt4.

Physicochemical Properties

M.Wt	503.52
Formula	C19H13N5O6S3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(5-((4-Nitrophenyl)sulfonyl)thiazol-2-yl)-2-((4-oxo-3,4-dihydroquinazolin-2-yl)thio)acetamide

References

1. Martin Pannek, et al. J Med Chem. 2024 Jan 22. doi: 10.1021/acs.jmedchem.3c01496.

UBCS373 (Sirt4 inhibitor 69)

Biological Activity

Physicochemical Properties

References

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