Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : UBCS373
Catalog No.: PC-21715Not For Human Use, Lab Use Only.
UBCS373 (Sirt4 inhibitor 69) is a highly isoform selective inhibitor of mitochondrial deacylase Sirtuin 4 (Sirt4) with IC50 of 16 uM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
UBCS373 (Sirt4 inhibitor 69) is a highly isoform selective inhibitor of mitochondrial deacylase Sirtuin 4 (Sirt4) with IC50 of 16 uM.
UBCS373 displays high selectivity against Sirt1, −2, −3, −5, and −6.
UBCS373 inhibits Sirt4 through binding to active site regions overlapping with the acyl-peptide binding regions but not with the NAD+ site.
UBCS373 dose-dependently increases GDH activity in both whole cells and mitochondrial extract of C2C12 mouse myoblast cells.
UBCS373 is active in cells and can serve as a chemical tool for physiological studies on Sirt4.
| M.Wt | 503.52 | |
| Formula | C19H13N5O6S3 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Martin Pannek, et al. J Med Chem. 2024 Jan 22. doi: 10.1021/acs.jmedchem.3c01496.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
