UHRF1 PHD inhibitor MLD4

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Chemical Structure : UHRF1 PHD inhibitor MLD4

Catalog No.: PC-72377Not For Human Use, Lab Use Only.

UHRF1 PHD inhibitor MLD4 is a specific compound that selectively inhibits the UHRF1-histone interaction (IC50=12.4 uM), targets the PHD finger of UHRF1, specifically disrupting histone H3 arginine 2 interactions with the PHD finger.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

UHRF1 PHD inhibitor MLD4 is a specific compound that selectively inhibits the UHRF1-histone interaction (IC50=12.4 uM), targets the PHD finger of UHRF1, specifically disrupting histone H3 arginine 2 interactions with the PHD finger.
UHRF1 PHD inhibitor MLD4 inhibited binding between H3K9me3(FAM) and UHRF1 with IC50 of 24-26 uM, displace UHRF1-histone H3 binding in cells.

Physicochemical Properties

M.Wt	416.522
Formula	C22H32N4O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N1-(2-(1-methylindolin-5-yl)-2-morpholinoethyl)-N2-((tetrahydrofuran-2-yl)methyl)oxalamide

References

1. Wallace H Liu, et al. Biochemistry. 2022 Feb 10.

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