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USP30 inhibitor Compound 39

Chemical Structure : USP30 inhibitor Compound 39

CAS No.: 2242582-40-5

USP30 inhibitor Compound 39 (CMPD-39, USP30inh, USP30 inhibitor)

Catalog No.: PC-72252Not For Human Use, Lab Use Only.

USP30 inhibitor Compound 39 (CMPD-39) is a highly selective inhibitor of USP30 with IC50 of 20 nM in an in vitro assay of enzyme activity, >100-fold selectivity over other DUBs.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

USP30 inhibitor Compound 39 (CMPD-39, USP30inh) is a highly selective inhibitor of USP30 with IC50 of 20 nM in an in vitro assay of enzyme activity, >100-fold selectivity over other DUBs.
CMPD-39 promotes depolarization-dependent ubiquitylation of previously described USP30 substrates (TOMM20, SYNJ2BP).
CMPD-39 enhanced basal mitophagy in treated SHSY5Y-mitoQC cells, enhanced basal pexophagy in treated U2OS-Keima-SKL cells.
CMPD-39 recapitulated the previously described effect for USP30 depletion in cell assays.

Physicochemical Properties

M.Wt 497.585
Formula C26H28FN3O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(αS)-N-[4-[[(1,1-Dimethylethyl)amino]sulfonyl]phenyl]-α-[(4-fluorobenzoyl)amino]benzenepropanamide

References

1. Emma V Rusilowicz-Jones, et al. Life Sci Alliance. 2021 Nov 29;5(2):e202101287.

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