VAS-2870 |CAS:722456-31-7 Probechem Biochemicals

Chemical Structure : VAS-2870

CAS No.: 722456-31-7

VAS-2870 (VAS2870;VAS 2870)

Catalog No.: PC-60724Not For Human Use, Lab Use Only.

VAS2870 (VAS-2870) potent, specific NADPH oxidase (Nox) inhibitor, completely abolishes PDGF-mediated NAD(P)H oxidase activation and ROS production at 10-20 uM in vascular smooth muscle cells (VSMC).

Packing	Price	Stock
5 mg	$78	In stock
10 mg	$118	In stock
25 mg	$188	In stock
50 mg	$298	In stock
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Biological Activity

VAS2870 (VAS-2870) potent, specific NADPH oxidase (Nox) inhibitor, completely abolishes PDGF-mediated NAD(P)H oxidase activation and ROS production at 10-20 uM in vascular smooth muscle cells (VSMC).
VAS-2870 abrogates thalidomide stimulation of cardiomyogenesis;
VAS-2870 also impairs cell growth and enhances TGF-β-induced apoptosis of liver tumor cells.

Physicochemical Properties

M.Wt	360.395
Formula	C18H12N6OS
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-benzyl-7-(2-benzoxazolyl)thio-1,2,3-triazolo[4,5-d]pyrimidine

References

1. ten Freyhaus H, et al. Cardiovasc Res. 2006 Jul 15;71(2):331-41.

2. Stielow C, et al. Biochem Biophys Res Commun. 2006 May 26;344(1):200-5.

3. Sancho P, et al. Biochem Pharmacol. 2011 Apr 1;81(7):917-24.

4. Kleinschnitz C, et al. PLoS Biol. 2010 Sep 21;8(9). pii: e1000479.

VAS-2870 (VAS2870;VAS 2870)

Biological Activity

Physicochemical Properties

References

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