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Chemical Structure : VE607
Catalog No.: PC-38897Not For Human Use, Lab Use Only.
VE607 is a specific small molecule inhibitor that block S protein-ACE2-mediated cellular entry of the SARS-CoV, inhibits pseudovirus entry with EC50 of 3 μM and inhibited SARS-CoV plaque formation with EC50 of 1.6 μM.
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VE607 is a specific small molecule inhibitor that block S protein-ACE2-mediated cellular entry of SARS-CoV, inhibits pseudovirus entry with EC50 of 3 μM and inhibited SARS-CoV plaque formation with EC50 of 1.6 μM.
VE607 does not protect Vero cells from poliovirus plaque formation.
VE607 broadly inhibits pseudoviral particles bearing the Spike from major VOCs (D614G, Alpha, Beta, Gamma, Delta, Omicron - BA.1 and BA.2) as well as authentic SARS-CoV-2 at low micromolar concentrations.
VE607 binds to the receptor binding domain (RBD)-ACE2 interface and stabilizes RBD in its "up" conformation.
| M.Wt | 392.540 | |
| Formula | C22H36N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kao RY, et al. Chem Biol. 2004 Sep;11(9):1293-9.
2. Ding S, et al. bioRxiv. 2022 Feb 22:2022.02.03.479007..
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