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Chemical Structure : VK2809
CAS No.: 852948-13-1
Catalog No.: PC-38030Not For Human Use, Lab Use Only.
VK2809 (VK-2809, MB-07811) is a potent, liver-specific thyroid hormone receptor β (THRβ) agonist for development for the treatment of hypercholesterolemia.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $358 | In stock | |
| 10 mg | $548 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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VK2809 (VK-2809, MB-07811) is a potent, liver-specific thyroid hormone receptor β (THRβ) agonist for development for the treatment of hypercholesterolemia.
VK2809 decreases hepatic triglyceride levels in GSD Ia mice through its simultaneous restoration of autophagy, mitochondrial biogenesis, and β-oxidation of fatty acids.
VK2809 (MB07811) is converted to MB07344 in liver microsomes.
VK2809 showed potent lipid lowering activity in the CFR (ED(50) 0.4 mg/kg, po) and good oral bioavailability (40%, rat).
| M.Wt | 514.983 | |
| Formula | C28H32ClO5P | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
trans-(S)-2-[[3,5-Dimethyl-4-(4-hydroxy-3-isopropylbenzyl)phenoxy]methyl]-4-(3-chlorophenyl)-2-oxo-[1,3,2]dioxaphosphorinane |
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1. Zhou J, et al. Thyroid. 2019 Aug;29(8):1158-1167.
2. Fujitaki JM, et al. Drug Metab Dispos. 2008 Nov;36(11):2393-403.
3. Boyer SH, et al. J Med Chem. 2008 Nov 27;51(22):7075-93.
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