Vandetanib (ZD6474) is a potent and selective VEGFR2 (KDR) inhibitor with IC50 of 40 nM.
Vandetanib (ZD6474) shows weak inhibition for VEGFR3 and EGFR (IC50 is 100 nM and 500 nM respectively).
Vandetanib (ZD6474) displays excellent selectivity over erbB2, MEK, CDK-2, Tie-2, IGFR-1R, PDK, PDGFRβ, and Akt (IC50=1.1-100 uM).
Vandetanib (ZD6474) has excellent solubility and good oral bioavailability.
