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Chemical Structure : WYE-125132
CAS No.: 1144068-46-1
Catalog No.: PC-42157Not For Human Use, Lab Use Only.
A potent, specific, ATP-competitive and orally active mTOR inhibitor with IC50 of 0.19 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $138 | In stock | |
| 25 mg | $228 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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WYE-125132 (WYE-132) is a potent, specific, ATP-competitive and orally active mTOR inhibitor with IC50 of 0.19 nM.
WYE-125132 dispalys high selectivity (>5,000-fold) over PI3Ks, the PI3K-related kinases hSMG1 and ATR, and a panel of 230 protein kinases.
WYE-125132 inhibits mTORC1-dependent phosphorylation of S6K(T389) and mTORC2-dependent phosphorylation of AKT(S473), inhibits cancer cell proliferation, cell cycle progression, and induces apoptosis.
WYE-125132 shows potent single-agent antitumor activity against multiple cancer models.
| M.Wt | 519.5954 | |
| Formula | C27H33N7O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 62 mg/mL |
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| Chemical Name/SMILES |
Urea, N-[4-[1-(1,4-dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-N'-methyl- |
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1. Yu K, et al. Cancer Res. 2010 Jan 15;70(2):621-31.
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