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Chemical Structure : YD-277
Catalog No.: PC-60426Not For Human Use, Lab Use Only.
YD-277 is a novel small molecule KLF5 inhibitor derived from ML264, demonstrates >10-fold enhanced efficacy in multiple cancer cell lines with IC50 of 1.5-10 uM.
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YD-277 is a novel small molecule KLF5 inhibitor derived from ML264, demonstrates >10-fold enhanced efficacy in multiple cancer cell lines with IC50 of 1.5-10 uM.
YD-277 decreases cancer cell viability in a KLF5-independent manner, induces G1 cell cycle arrest and promotes apoptosis through activating IRE1α in MDA-MB-231 and MDA-MB-468 cell.
YD-277 significantly inhibits the growth of MDA-MB-231 tumor xenografts in nude mice.
| M.Wt | 435.949 | |
| Formula | C22H30ClN3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Chen Z, et al. Theranostics. 2017 Jun 11;7(8):2339-2349.
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