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Chemical Structure : YKL 06-061
CAS No.: 2172617-15-9
Catalog No.: PC-63122Not For Human Use, Lab Use Only.
YKL06-061 is a potent, selective, second-generation salt-inducible kinase (SIK) inhibitor with IC50 of 6.56/1.77/20.5 nM for SIK1/2/3, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $158 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | Get quote |
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YKL06-061 is a potent, selective, second-generation salt-inducible kinase (SIK) inhibitor with IC50 of 6.56/1.77/20.5 nM for SIK1/2/3, respectively.
YKL06-061 inhibits only one kinase FRK (IC50=1.1 nM), more strongly than SIKs, in a panel of 468 human kinases.
YKL06-061 dose-dependently increases MITF mRNA expression in human melanoma cells.
YKL06-061 induces significant pigmentation in Mc1r-deficient mice and normal human skin.
| M.Wt | 527.673 | |
| Formula | C30H37N7O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Pyrimido[4,5-d]pyrimidin-2(1H)-one,1-cyclobutyl-3-(2,6-dimethylphenyl)-3,4-dihydro-7-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]- |
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1. Mujahid N, et al. Cell Rep. 2017 Jun 13;19(11):2177-2184.
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