Chemical Structure : YZL-51N
CAS No.:
3031072-69-9
YZL-51N
(SIRT7 inhibitor)
Catalog No.: PC-22579Not For Human Use, Lab Use Only.
YZL-51N is a potent, selective, NAD+ competitive SIRT7 inhibitor with IC50 of 12.7 uM in Fluor de Lys (FDL) assays, inhibits SIRT7-mediated H3K18ac deacetylation with EC50 of 13.5 uM in dot blot assays.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
YZL-51N is a potent, selective, NAD+ competitive SIRT7 inhibitor with IC50 of 12.7 uM in Fluor de Lys (FDL) assays, inhibits SIRT7-mediated H3K18ac deacetylation with EC50 of 13.5 uM in dot blot assays.
YZL-51N selectively inhibits SIRT7 deacetylase activity, does not inhibit the deacetylase activities of other sirtuins.
YZL-51N shows potent interactionfor SIRT7 with KD of 3.3 uM in bio-layer interferometry (BLI) assays.
YZL-51N specifically suppresses SIRT7 enzymatic activities in colorectal cancer cells, increases the level of H3K18ac in HCT116 cells.
YZL-51N attenuates DNA damage repair, shows potential for anti-tumor on colorectal cancers.
Physicochemical Properties
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M.Wt
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330.29
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Formula
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C17H14O7
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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methyl (Z)-2,4-bis(3,4-dihydroxyphenyl)-4-oxobut-2-enoate
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References
1. Tian-Shu Kang, et al. iScience. 2024 May 16;27(6):110014.
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