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Chemical Structure : YZL-51N
Catalog No.: PC-22579Not For Human Use, Lab Use Only.
YZL-51N is a potent, selective, NAD+ competitive SIRT7 inhibitor with IC50 of 12.7 uM in Fluor de Lys (FDL) assays, inhibits SIRT7-mediated H3K18ac deacetylation with EC50 of 13.5 uM in dot blot assays.
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YZL-51N is a potent, selective, NAD+ competitive SIRT7 inhibitor with IC50 of 12.7 uM in Fluor de Lys (FDL) assays, inhibits SIRT7-mediated H3K18ac deacetylation with EC50 of 13.5 uM in dot blot assays.
YZL-51N selectively inhibits SIRT7 deacetylase activity, does not inhibit the deacetylase activities of other sirtuins.
YZL-51N shows potent interactionfor SIRT7 with KD of 3.3 uM in bio-layer interferometry (BLI) assays.
YZL-51N specifically suppresses SIRT7 enzymatic activities in colorectal cancer cells, increases the level of H3K18ac in HCT116 cells.
YZL-51N attenuates DNA damage repair, shows potential for anti-tumor on colorectal cancers.
| M.Wt | 330.29 | |
| Formula | C17H14O7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Tian-Shu Kang, et al. iScience. 2024 May 16;27(6):110014.
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