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ZAP180013

Chemical Structure : ZAP180013

CAS No.: 873080-25-2

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ZAP180013 (ZAP-180013)

Catalog No.: PC-38018Not For Human Use, Lab Use Only.

ZAP 180013 is a small molecule inhibitor of zeta-chain-associated protein kinase 70 (Zap70) with IC50 of 1.8 uM (fluorescence polarization assay).

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Biological Activity

ZAP 180013 is a small molecule inhibitor of zeta-chain-associated protein kinase 70 (Zap70) with IC50 of 1.8 uM (fluorescence polarization assay).
ZAP 180013 inhibits the interaction of Zap70 SH2 domain with immunoreceptor tyrosine-based activation motif (ITAMs), within the T-cell antigen receptor (TCR) signaling pathway.

Physicochemical Properties

M.Wt 454.32
Formula C19H17Cl2N3O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-Chloro-N-[(4-chlorophenyl)methyl]-2-(ethylsulfonyl)-N-(2-furanylmethyl)-4-pyrimidinecarboxamide

References

1. Patrick R Visperas, et al. SLAS Discov. 2017 Mar;22(3):324-331.

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