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ZCZ011

Chemical Structure : ZCZ011

CAS No.: 1998197-39-9

ZCZ011 (ZCZ 011, ZCZ-011)

Catalog No.: PC-73251Not For Human Use, Lab Use Only.

ZCZ011 is a positive allosteric modulator of CB1 receptor, increases specific binding of CB1 receptor orthosteric agonist [3H]CP55,940 to mouse brain membranes with pEC50 of 6.9.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ZCZ011 is a positive allosteric modulator of CB1 receptor, increases specific binding of CB1 receptor orthosteric agonist [3H]CP55,940 to mouse brain membranes with pEC50 of 6.9.
ZCZ011 also produced a significant and concentration-dependent increase in the specific binding of the CB1 receptor orthosteric agonist [3H]WIN55212 to mouse brain membranes with pEC50 of 6.3.
ZCZ011 significantly enhanced AEA-stimulated [35S]GTPγS binding at 100 nM.
ZCZ011 potentiated β-arrestin recruitment, and ERK phosphorylation assays.
ZCZ011 is brain penetrant, exhibits antinociceptive effects in neuropathic and inflammatory pain models with no associated cannabimimetic effects.

Physicochemical Properties

M.Wt 362.44
Formula C21H18N2O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

6-Methyl-3-[2-nitro-1-(2-thienyl)ethyl]-2-phenyl-1H-indole

References

1. Ignatowska-Jankowska BM, et al. Neuropsychopharmacology. 2015 Dec;40(13):2948-59.

2. Mitjavila J, et al. Pharmacol Res. 2018 Mar;129:475-481.

3. Saleh N, et al. Angew Chem Int Ed Engl. 2018 Mar 1;57(10):2580-2585.

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