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Chemical Structure : ZLN-024 hydrochloride
CAS No.: 1883548-91-1
Catalog No.: PC-45055Not For Human Use, Lab Use Only.
ZLN-024 hydrochloride is a potent, allosteric AMPK activator that has no effect on mitochondrial function or the ADP/ATP ratio, directly activate recombinant AMPK α1β1γ1 and its homologue α2β1γ1 with EC50 of 0.42 uM and 0.95 uM, respectively.
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|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $368 | In stock | |
| 100 mg | Get quote |
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ZLN-024 hydrochloride is a potent, allosteric AMPK activator that has no effect on mitochondrial function or the ADP/ATP ratio, directly activate recombinant AMPK α1β1γ1 and its homologue α2β1γ1 with EC50 of 0.42 uM and 0.95 uM, respectively.
ZLN-024 also directly activate recombinant AMPK α1β2γ1 (EC50=1.1 µuM) and AMPK α2β2γ1 (EC50=0.13 uM).
ZLN-024 activates AMPK in L6 myotubes and stimulates glucose uptake and fatty acid oxidation.
ZLN-024 improves glucose tolerance, liver tissue weight, triacylglycerol and decreases the total cholesterol content in db/db mice (15 mg/kg/day).
| M.Wt | 361.6851 | |
| Formula | C13H14BrClN2OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 46 mg/mL |
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| Chemical Name/SMILES |
Pyrimidine, 2-[[2-(2-bromo-4-methylphenoxy)ethyl]thio]-, hydrochloride |
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1. Zhang LN, et al. PLoS One. 2013 Aug 20;8(8):e72092.
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