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Chemical Structure : dBRD9‐A
Catalog No.: PC-72322Not For Human Use, Lab Use Only.
dBRD9‐A is a chemical degrader (PROTAC) of BRD9, a highly specific binder of the BRD9 bromodomain and elicits near complete BRD9 degradation at low nanomolar concentrations.
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dBRD9‐A is a chemical degrader (PROTAC) of BRD9, a highly specific binder of the BRD9 bromodomain and elicits near complete BRD9 degradation at low nanomolar concentrations.
dBRD9‐A blocks synovial sarcoma tumour progression and oncogenic transcription.
dBRD9‐A limited IFN‐induced expression of certain ISGs in multiple cell types, significantly reduced induction of 29 ISGs, including many ISGs known to harbor antiviral activity against the viruses, such as MX1, MX2, IFITM1, IFITM3, IDO1, and BST2.
| M.Wt | 779.895 | |
| Formula | C42H49N7O8 | |
| Appearance | Solid | |
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1. Gerard L Brien, et al. Elife. 2018 Nov 15;7:e41305.
2. Jacob Börold, et al. EMBO Rep. 2021 Oct 5;22(10):e52823.
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