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inh-02

Chemical Structure : inh-02

CAS No.: 324579-65-9

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inh-02 (RNF5 inhibitor inh-02)

Catalog No.: PC-35074Not For Human Use, Lab Use Only.

inh-02 (RNF5 inhibitor inh-02) is a novel small molecule inhibitor of E3 ubiquitin ligase RNF5/RMA1.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

inh-02 (RNF5 inhibitor inh-02) is a novel small molecule inhibitor of E3 ubiquitin ligase RNF5/RMA1; causes significant F508del-CFTR rescue (EC50=2.2 uM) in immortalized and primary bronchial epithelial cells from CF patients homozygous for the F508del mutation, decreases ubiquitylation of mutant CFTR, causing stabilization of the mature form of CFTR; inh-2 acts on ATG4B and paxillin, which are known targets downstream of RNF5.

Physicochemical Properties

M.Wt 384.501
Formula C23H20N4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(E)-N-((Z)-4-benzyl-3-methyl-1,2,4-thiadiazol-5(4H)-ylidene)-N'-phenylbenzimidamide

References

1. Sondo E, et al. Cell Chem Biol. 2018 Apr 26. pii: S2451-9456(18)30124-7.

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