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kb-NB142-70

Chemical Structure : kb-NB142-70

CAS No.: 1233533-04-4

kb-NB142-70 (kb NB 142-70)

Catalog No.: PC-63036Not For Human Use, Lab Use Only.

kb NB142-70 is a potent and selective PKD inhibitor with IC50 of 28.3 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

kb NB142-70 is a potent and selective PKD inhibitor with IC50 of 28.3 nM.
kb NB142 70 displays 10-fold increase in the in vitro PKD1 inhibitory potency versus CID755673.
kb NB142 70 inhibits PC-3, PANC-1, CFPAC-1 cellular growth with IC50 of 5-30 uM.

Physicochemical Properties

M.Wt 251.318
Formula C11H9NO2S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3,4-dihydro-9-hydroxy-[1]benzothieno[2,3-f]-1,4-thiazepin-5(2H)-one

References

1. Bravo-Altamirano K, et al. ACS Med Chem Lett. 2011 Feb 14;2(2):154-159.

2. Guo J, et al. Cancer Chemother Pharmacol. 2013 Feb;71(2):331-44.

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