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Chemical Structure : p62-ZZ ligand YOK-1304
CAS No.: 2409960-02-5
Catalog No.: PC-72925Not For Human Use, Lab Use Only.
YOK-1304 is a small molecule p62-ZZ domain ligand, activate p62-dependent selective macroautophag, used for AUTOTAC design.
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|---|---|---|---|
| 5 mg | $358 | In stock | |
| 10 mg | $528 | In stock | |
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YOK-1304 is a small molecule p62-ZZ domain ligand, activate p62-dependent selective macroautophag, used for AUTOTAC design.
AUTOphagy-TArgeting Chimera (AUTOTAC) is a general chemical tool and platform technology, which employs bifunctional molecules composed of target-binding ligands linked to autophagy-targeting ligands.
AUTOTACs bind the ZZ domain of the otherwise dormant autophagy receptor p62/Sequestosome-1/SQSTM1, which is activated into oligomeric bodies in complex with targets for their sequestration and degradation.
| M.Wt | 435.564 | |
| Formula | C27H33NO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(R)-1-(4-(benzyloxy)-3-phenethoxyphenoxy)-3-(isopropylamino)propan-2-ol |
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1. Chang Hoon Ji, et al. Nat Commun. 2022 Feb 16;13(1):904.
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