Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : α2β1 integrin-IN-15
Catalog No.: PC-62071Not For Human Use, Lab Use Only.
α2β1 integrin-IN-15 highly potent, selective, allosteric small-molecule inhibitor of integrin α2β1 with IC50 of 12 nM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
α2β1 integrin-IN-15 highly potent, selective, allosteric small-molecule inhibitor of integrin α2β1 with IC50 of 12 nM; ihibits adhesion of cells expressing wild-type (WT) and demonstrates no effect on RBL cells expressing an activating I-domain mutation (E318A), inhibits an activating cytoplasmic domain mutant [Del(GFFKR)] with an IC50 ≈4-fold higher than for wild-type integrin α2β1; shows efficacious activity in an animal model of arterial thrombosis.
| M.Wt | 520.619 | |
| Formula | C23H28N4O6S2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Miller MW, et al. Proc Natl Acad Sci U S A. 2009 Jan 20;106(3):719-24.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
