Chemical Structure : α2β1 integrin-IN-15
Catalog No.: PC-62071Not For Human Use, Lab Use Only.
α2β1 integrin-IN-15 highly potent, selective, allosteric small-molecule inhibitor of integrin α2β1 with IC50 of 12 nM.
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α2β1 integrin-IN-15 highly potent, selective, allosteric small-molecule inhibitor of integrin α2β1 with IC50 of 12 nM; ihibits adhesion of cells expressing wild-type (WT) and demonstrates no effect on RBL cells expressing an activating I-domain mutation (E318A), inhibits an activating cytoplasmic domain mutant [Del(GFFKR)] with an IC50 ≈4-fold higher than for wild-type integrin α2β1; shows efficacious activity in an animal model of arterial thrombosis.
M.Wt | 520.619 | |
Formula | C23H28N4O6S2 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
1. Miller MW, et al. Proc Natl Acad Sci U S A. 2009 Jan 20;106(3):719-24.
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