NEDD8-activating Enzyme (NAE) (inhibitors, antagonists, agonists)-ProbeChem.com

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Cat. No.	Product Name	Information
PC-72994	TAS4464 NEDD8-activating enzyme inhibitor	TAS4464 (TAS-4464) is a highly potent and selective inhibitor of NEDD8-activating enzyme (NAE) with IC50 of 0.955 nM, >400-fold selectivity over UAE and SAE.
PC-62879	NEDD8 inhibitor M22 NEDD8-activating enzyme inhibitor	NEDD8 inhibitor M22 is a novel, potent, selective reversible NEDD8 activating enzyme (NAE) inhibitor.
PC-60350	ABP-A3 NEDD8-activating enzyme inhibitor	ABP-A3(ABP A3) is an inhibitor of ubiquitin conjugation that targets ubiquitin and Nedd8 E1 enzymes.
PC-45949	Pevonedistat NEDD8-activating enzyme inhibitor	MLN4924 (Pevonedistat, TAK-924) is an analog of adenosine 5’-monophosphate that potently and selectively inhibits NEDD8-activating enzyme (NAE) with IC50 of 4.7 nM.
PC-42613	MLN4924 hydrochloride NEDD8-activating enzyme inhibitor	MLN4924 (Pevonedistat) hydrochloride is an analog of adenosine 5’-monophosphate that potently and selectively inhibits NEDD8-activating enzyme (NAE) with IC50 of 4.7 nM.
PC-27546	HA-218-6-31-80 NAE inhibitor	HA-218-6-31-80 is a novel NEDD8-activating enzyme (NAE) inhibitor, directly binds NAE and suppresses its catalytic activity, blocks the formation of E2-NEDD8 thioesters, and reduces the neddylation of CUL1 and CUL5 in purified protein systems.

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